Basic Information
| LncRNA/CircRNA Name | circCEP128 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR, Immunohistochemistry, Western blot, FISH, Flow cytometry (FCM) assay, MTT assay, Luciferase reporter assay, RNA pull-down assay, Tunnel staining, EdU incorporation |
| Sample | bladder tumor tissues, bladder cancer cells lines (RT-112, 5637, BIU-87 and TCCSUP) and human embryonic kidney cells lines (HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | circCEP128 and SOX11 were observed significantly up-regulated in bladder cancer tissues, while the expression of miR-145-5p was decreased in cancer samples compared to normal samples. Cytoscape was used to visualize circCEP128-miRNA-target gene interactions based on the TargetScan and circular RNA interactome, which revealed that circCEP128 served as a sponge of miR-145-5p and indirectly regulated SOX11. Knockdown of circCEP128 induced the inhibition of cell proliferation and the increased bladder cancer cell apoptosis rate. |
| Pubmed ID | 30134837 |
| Year | 2018 |
| Title | Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11 |
External Links
| Links for circCEP128 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |