Basic Information
| LncRNA/CircRNA Name | circ_0007534 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Cell proliferation detection, Cell apoptosis detection, Relative caspases activity determination, Antibodies and immunoblotting analyses, IHC |
| Sample | OS tissue, bone cell line (hFOB1.19) and OS cells including HOS, Saos2, MG63, and U2OS |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0007534 is overexpressed in OS tissue samples and cells and this up-regulation is related with larger tumor size and poorer differentiation degree. Moreover, hsa_circ_0007534 is a dismal prognostic biomarker for OS patients. For the functional assays, knockdown of hsa_circ_0007534 suppresses OS cell growth in vitro and in vivo. In addition, hsa_circ_0007534 protects against cell apoptosis via Bcl-2/caspase-3 pathway. Furthermore, AKT/GSK-3? pathway could be activated by hsa_circ_0007534 to facilitate OS progression. |
| Pubmed ID | 30142548 |
| Year | 2018 |
| Title | Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3? signaling pathway |
External Links
| Links for circ_0007534 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |