Basic Information
| LncRNA/CircRNA Name | circVANGL1 |
| Synonyms | circ_0002623 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | Biotin??oupled probe pull??own assay, Cell cycle analysis, Migration and invasion assays, Fluorescence in situ hybridization, Western blot, CCK??, Colony formation assay, Luciferase assays, qRT-PCR, Tumor xenograft assay |
| Sample | BC tissues, BC cell lines: T24, 253J, UMUC??, J82, 5637 and EJ |
| Expression Pattern | up-regulated |
| Function Description | circ-VANGL1 was highly expressed in BC tissues compared with adjacent normal tissues. Furthermore, we showed that circ-VANGL1 could serve as a prognostic marker for patients with BC. Through functional experiments, we found that circ-VANGL1 knockdown significantly suppressed BC cell proliferation, cell cycle, migration, and invasion in vitro. Besides, circ-VANGL1 silence inhibited BC cell propagation in vivo. Mechanistically, we identified circ-VANGL1 as a sponge of miR-605-3p which targeted VANGL1 in BC cells. Through repressing miR-605-3p availability, circ VANGL1 contributes to VANGL1 expression, consequently leading to BC cell proliferation, migration, and invasion. |
| Pubmed ID | 30146736 |
| Year | 2018 |
| Title | Circular RNA circ??ANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR??05??p/VANGL1 pathway |
External Links
| Links for circVANGL1 | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |