Basic Information
| LncRNA/CircRNA Name | circ_0102533 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Small interfering RNA transfection, CCK-8, Flow cytometry for apoptosis, Caspase-3 activity assay |
| Sample | whole blood and NSCLC tissues, bronchial epithelial cells (NHBE) and NSCLC cell lines (A549, H1299, H1792, SK-MES-1 and SPC-A1) |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0102533 expression was significantly increased in tumor tissues and whole blood from NSCLC patients. Furthermore, the knockout of hsa_circ_0102533 by siRNA significantly inhibited proliferation and induced apoptosis in NSCLC cell lines. |
| Pubmed ID | 31949836 |
| Year | 2018 |
| Title | Hsa_circ_0102533 serves as a blood-based biomarker for non-small-cell lung cancer diagnosis and regulates apoptosis in vitro |
External Links
| Links for circ_0102533 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |