Basic Information
| LncRNA/CircRNA Name | circ_100395 |
| Synonyms | circ_0015278 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | MTT assay, Transwell assay, RNA pulldown, qRT-PCR, RNA-FISH, Luciferase reporter assay, In vivo assay |
| Sample | lung cancer tissues, lung cancer cell lines (A549, H460, PC9, H1299, H1975 and SPC-A1) |
| Expression Pattern | down-regulated |
| Function Description | hsa_circ_100395 expression was decreased in lung cancer tissues.?Besides, hsa_circ_100395 level was inversely correlated with TNM stage and metastases in lung cancer and low hsa_circ_100395 expression in patients predicted poor prognosis.?Overexpression of hsa_circ_100395 dramatically inhibited lung cancer cell proliferation, arrested cell-cycle progression and reduced cell migration and invasion in vitro.?Xenograft experiments showed that hsa_circ_100395 overexpression delayed tumor growth in vivo.Mechanistically, we showed hsa_circ_100395 serves as a sponge for miR-1228 targeting TCF21 in lung cancer.?Rescue assays indicated that hsa_circ_100395 regulates lung cancer cell proliferation, migration and invasion through modulating miR-1228/TCF21 pathway. |
| Pubmed ID | 30176158 |
| Year | 2018 |
| Title | CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression |
External Links
| Links for circ_100395 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |