Basic Information
| LncRNA/CircRNA Name | circ_0072995 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qRT-PCR, Cell migration assays, Cell invasion assay, Dual luciferase activity assay, FISH |
| Sample | breast cancer cell lines MCF-7 and MDA-MB-231 |
| Expression Pattern | up-regulated |
| Function Description | Hsa_circ_0072995 was significantly upregulated in MDA-MB-231 cells compared with MCF-7 cells. Hsa_circ_0072995 regulated the invasion and migration of breast cancer cells. Hsa circ 0072995 existed in the nucleus and cytoplasm, and the proportion of the two was roughly equal. Hsa_circ_0072995 bound to miR-30c-2-3p. Overexpression of miR-30c-2-3p inhibited breast cancer cells migration and invasion. Low expression of miR-30c-2-3p was correlated with poor overall survival by The Cancer Genome Atlas database. |
| Pubmed ID | 30182731 |
| Year | 2018 |
| Title | Circular RNA hsa circ 0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p |
External Links
| Links for circ_0072995 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |