Basic Information
| LncRNA/CircRNA Name | circ_0080145 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | chronic myeloid leukemia |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Dual luciferase reporter assay, Cell proliferation assay and colony formation |
| Sample | CML tissues, CML cell lines including K562 and KU812, normal mesenchymal stem cells (MSCs) |
| Expression Pattern | differentially expressed |
| Function Description | high-throughput sequencing was performed to explore the expression profile of circRNAs in CML patients for the first time, and a large number of differentially expressed circRNAs were identified. In addition, we constructed potential circRNA-miRNA interaction networks in CML, including a detailed hsa_circ_0080145-mediated competing endogenous RNA (ceRNA) regulatory network. Furthermore, functional experiments demonstrated that hsa_circ_0080145 knockdown significantly suppressed CML cell proliferation and hsa_circ_0080145 regulated CML cell proliferation by acting as an miR-29b sponge. |
| Pubmed ID | 30205959 |
| Year | 2018 |
| Title | Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR29b |
External Links
| Links for circ_0080145 | GenBank HGNC NONCODE |
| Links for chronic myeloid leukemia | OMIM COSMIC |