Basic Information
| LncRNA/CircRNA Name | circNEK6 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qRT-PCR, Western blot, Dual luciferase reporter assay, MTT assay, Transwell assay, Cell apoptosis assay |
| Sample | thyroid cancer tissues, thyroid cancer cell lines TPC-1 and FTC-133, normal thyroid cell line Nthy-ori 3?? |
| Expression Pattern | up-regulated |
| Function Description | CircNEK6 and FZD8 were significantly up-regulated in thyroid cancer, with strong correlations. The Wnt signaling pathway was activated in thyroid cancer. MiR-370-3p was the common target miRNA of circNEK6 and FZD8, and it was down-regulated in thyroid cancer. Overexpression of circNEK6 and FZD8 could promote the growth and invasion of thyroid cancer cells, while up-regulation of miR-370-3p could suppress thyroid cancer progression and inhibit the Wnt signaling pathway. MiR-370-3p s effect on thyroid cancer cells could be rescued by circNEK6 or FZD8 |
| Pubmed ID | 30207869 |
| Year | 2018 |
| Title | Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway |
External Links
| Links for circNEK6 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |