Basic Information
| LncRNA/CircRNA Name | circ_0000993 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Fluorescent in situ hybridization, Wound-healing assay, Transwell invasion assay, The MTT cell proliferation assay, Luciferase reporter assay |
| Sample | gastric cancer tissues, gastric cancer cell lines SGC-7901 and BGC-823 |
| Expression Pattern | down-regulated |
| Function Description | hsa_circ_0000993 inhibited migration, invasion and proliferation of gastric cancer cells and could act as a miRNA sponge for miR-214-5p but did not modulate expression of its parental gene, ATL2. Survival analysis showed that gastric cancer patients with lowly expressed miR-214-5p had a significantly better overall survival. |
| Pubmed ID | 30215537 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells |
External Links
| Links for circ_0000993 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |