Basic Information
| LncRNA/CircRNA Name | circ_0025039 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Colony formation assays, CCK-8 assay, Cell invasion assay, Western blot, Pull down assay, IHC assay, Nude mouse tumorigenicity assay |
| Sample | melanoma tumor tissues, cell lines HEMn, A375, SK-MEL-1, A2058 and 293 T |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0025039, which is formed by FOXM1 exons, is significantly upregulated in melanoma. In vitro, the knockdown of circ_0025039 inhibited cell proliferation, colony formation ability, invasion and glucose metabolism in melanoma cells. Additionally, we identified miR-198 as a direct target of hsa_- circ_0025039. Furthermore, we demonstrated that hsa_circ_0025039 regulates CDK4 expression by sponging miR-198. In vivo study indicated that the silencing of hsa_circ_0025039 inhibits melanoma tumor formation and downregulates miR-198 and CDK4 expression. |
| Pubmed ID | 30219673 |
| Year | 2018 |
| Title | Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis |
External Links
| Links for circ_0025039 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |