Basic Information
| LncRNA/CircRNA Name | circ_0061140 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | Cell Proliferation Assay, Western blotting, Fluorescence In Situ Hybridization, Wound-Healing Assay, Transwell Migration Assay, Luciferase Reporter Assay, RT-qPCR |
| Sample | normal ovarian epithelial cells, ovarian cancer cell lines SKOV3, A2780, OV2008, IGROV1, and ES-2, Xenograft Assays |
| Expression Pattern | up-regulated |
| Function Description | hsa_circ_0061140 was upregulated in ovarian cancer cell lines. Knockdown of hsa_circ_0061140 suppressed cell proliferation and migration, both in vivo and in vitro, by inhibiting FOXM1 expression through sponging miR-370. Overexpression of FOXM1 or suppression of miR-370 rescued hsa_circ_0061140 silencing-induced inhibition of cell proliferation, migration, and the EMT. The associations among hsa_circ_0061140, miR-370, and FOXM1 were confirmed via bioinformatic prediction and fluorescein reporter experiments. Thus, hsa_circ_0061140 appeared to function as a competing endogenous RNA of miR-370 that promoted cell growth and metastasis in ovarian cancer through regulation of the miR-370/ FOXM1 pathway mediating EMT. |
| Pubmed ID | 30236833 |
| Year | 2018 |
| Title | hsa_circ_0061140 Knockdown Reverses FOXM1-Mediated Cell Growth and Metastasis in Ovarian Cancer through miR-370 Sponge Activity |
External Links
| Links for circ_0061140 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |