Basic Information
| LncRNA/CircRNA Name | circITCH |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR, Cell proliferation assay, Cell motility assay, Dual luciferase reporter assays, In vivo tumor growth assays |
| Sample | ovarian carcinoma tissues, OC cell lines SK-OV-3 and Caov-3 |
| Expression Pattern | down-regulated |
| Function Description | Here, we found a broad down-regulation of circ-ITCH in OC tissues and cells, which correlates with a worse prognosis in OC patients. Functional studies suggest that circ-ITCH overexpression inhibits the cell viability and motility by CCK8, cell cycle, wound healing assay and invasion assay. It also inhibits the tumorigenesis ability in xenograft NOD mice in vivo. Mechanically, we demonstrated that circ-TCH acts as a ceRNA to sponge miR-145, increases the level of RASA1, and inhibits the malignant progression of OC cells via the circ-ITCH-miR-145-RASA1 axis in vitro and in vivo. |
| Pubmed ID | 30243714 |
| Year | 2018 |
| Title | The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling |
External Links
| Links for circITCH | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |