Basic Information
| LncRNA/CircRNA Name | circ_0043898 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | RNA-seq, PCR |
| Sample | esophageal cancerous tissues, cell lines HEEC, Kyse-140, Kyse-510, Kyse-520, Kyse-30, TE-1 and ECA-109 |
| Expression Pattern | down-regulated |
| Function Description | circ0043898 was validated that down-regulated expressed in the specimens from the patients with esophageal carcinoma. The cell assays proved that overexpression of circ0043898 can obviously inhibit the cell proliferation, cell migration and invasion and induce cell apoptosis and death in the cancerous cells. The in vivo animal study also suggested that the circ0043898 performed inhibitory functions on oncogenesis. The RNA-seq presented the potential regulation mechanism of circ0043898. Histone H3 and BMI1 were presented significantly differential expression in both ECA-109 and Kyse-520 cells, indicating they might be the targets of circ0043898. |
| Pubmed ID | 30252576 |
| Year | 2018 |
| Title | Circ0043898 acts as a tumor inhibitor and performs regulatory effect on the inhibition of esophageal carcinoma |
External Links
| Links for circ_0043898 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |