Basic Information
| LncRNA/CircRNA Name | circ_0052112 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Cell migration assays, Cell invasion assay, Dual luciferase activity assay, FISH |
| Sample | breast cancer cell line MCF-7 and MDA-MB-231 |
| Expression Pattern | up-regulated |
| Function Description | Hsa_circ_0052112 expression was significantly higher in MDA-MB-231 cells than that in MCF-7 cells. Overexpression of hsa_circ_0052112 promoted cell migration and invasion in breast cancer. Inversely, downregulation of hsa_circ_0052112 suppressed breast cancer cells migration and invasion. Hsa_circ_0052112 was mostly located in cytoplasm. Hsa_circ_0052112 could directly sponge to miR-125a-5p; overexpression of miR125a-5p significantly inhibited breast cancer cells migration and invasion. |
| Pubmed ID | 30257349 |
| Year | 2018 |
| Title | Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer |
External Links
| Links for circ_0052112 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |