Basic Information
| LncRNA/CircRNA Name | circPRMT5 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | exosome | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | urothelial cancer |
| ICD-0-3 | NA |
| Methods | RT-PCR, Western blot, RIP |
| Sample | UCB tissues, serum and urine exosomes, UCB cell lines (i.e., T24, TCC-SUP, 5637, UM-UC-3) and a non-tumorous bladder cell line, SV-HUC-1 |
| Expression Pattern | up-regulated |
| Function Description | We demonstrated that upregulated expression of circPRMT5 was positively associated with advanced clinical stage and worse survival in UCB patients. We further revealed that circPRMT5 promoted UCB cell EMT via sponging miR-30c. Clinical analysis from two independent UCB cohorts showed that the circPRMT5/miR-30c/SNAIL1/E-cadherin pathway was essential in supporting UCBs progression. Importantly, we identified that circPRMT5 was up-regulated in serum and urine exosomes from UCB patients, and significantly correlated with tumor metastasis. |
| Pubmed ID | 30305293 |
| Year | 2018 |
| Title | PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition |
External Links
| Links for circPRMT5 | GenBank HGNC NONCODE |
| Links for urothelial cancer | OMIM COSMIC |