Basic Information
| LncRNA/CircRNA Name | circ_001569 |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | RT??PCR, Cell proliferation assay, Cell colony formation assay, Western blot |
| Sample | primary osteosarcoma tissue, osteosarcoma cell lines (MG??3 and U2OS) and normal human osteoblastic cell line hFOB |
| Expression Pattern | up-regulated |
| Function Description | circ_001569 expression was significantly overexpressed in osteosarcoma tissues compared with adjacent noncancerous bone tissues. Higher circ_001569 expression significantly correlated with distant metastasis and advanced tumor stage of osteosarcoma patients. Gain-function and loss-function assays showed that circ_001569 knockdown significantly inhibited osteosarcoma cell proliferation and cell colon formation capacities. Moreover, upregulation of circ_001569 significantly promoted osteosarcoma cell resistance to cisplatin by activating Wnt/?-catenin signaling pathway. |
| Pubmed ID | 30344736 |
| Year | 2018 |
| Title | Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/???atenin signaling pathway |
External Links
| Links for circ_001569 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |