Super-Enhancer Archive is a web based comprehensive resource focuses on the collection, storage and online analysis of super-enhancers. Our mission is to provide a curated set of information datasets for super-enhancers and tools in mutiple genomes, to support and promote research in this area. Especially, we provide a genome-scale landscape to show super-enhancer information in a scalable and flexible manner.
Currently, Super-Enhancer Archive consists of super-enhancers in Human, Mouse and two key model organisms,including 75, 439 human super-enhancers, 5, 879 mouse super-enhancers, 1, 774 D. melanogaster super-enhancers and 904 C. elegans super-enhancers respectively. Super-Enhancer Archive supports analysis and chart view of these datasets, download for further analysis and can be even easily visualized in the genome browser (SEA-Browser).
Further information of citation, updates and statistics are available in this page. This site is updating regularly.
Super-enhancers are genome regions that are large clusters of transcriptional enhancers and drive expression of genes that define cell identity. The term “super-enhancer” was motioned for the first time by Chen et al. in 2004 (Chen, Yao et al. 2004). They are identified in large-scale by Richard A. Young and his colleagues in 2013 (Chapuy, McKeown et al. 2013, Hnisz, Abraham et al. 2013). It has been reported that super-enhancers differ from typical enhancers in size, transcription factor density and content, and the ability to activate transcription (Chapuy, McKeown et al. 2013). And Super-enhancers are regarded as the regulators of cell identity, ESC state maintenance, and tumor pathogenesis.
For more information about super-enhancers, please go to the Documentation page in which the studies about super-enhancers are subtotaled.
(Hnisz, D., Abraham, B.J., Lee, T.I., Lau, A., Saint-Andre, V., Sigova, A.A., Hoke, H.A. and Young, R.A. (2013) Super-enhancers in the control of cell identity and disease. Cell, 155, 934-947.)
New - Super-Enhancer Archive is nearly the first integrated and interactive database of super-enhancers up to now as we know.
Comprehensive - It contains the super-enhancers identified in different cell/tissue types of multiple model species (Human, Mouse, Drosophila melanogaster, and Caenorhabditis elegans).
Convenient - It is convenient for biologists to query super-enhancer and its' related information of interested topics.
Functional - Function annotation could be done by integrated online analysis tools (SEA-Browser, TFBS enrichment, H3K27ac enrichment and GREAT).
Super-Enhancers have crucial functions in genome, just like the lighthouse illuminating the road ahead, they drive cell-type-specific extremely high expression of genes that define cell identity in development and disease.